Prophylactic, prandial rofecoxib treatment lacks efficacy against acute PTZ-induced seizure generation and kindling acquisition
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چکیده
منابع مشابه
Retinol and ?-Carotene inhibit PTZ-induced kindling in mice
Vitamin A and its derivatives have recently reported to be implicated in synaptic plasticity. The possible effect of vitamin A and its precursor, ?-carotene, on seizure acquisition was tested in PTZ kindling model of epilepsy. Vitamin A and ?-carotene were tested for their ability to 1) suppress seizures (clonic and tonic) and lethality induced by PTZ in PTZ-kindled mice (anticonvulsant effect)...
متن کاملAnticonvulsant Activity of Teucrium polium Against Seizure Induced by PTZ and MES in Mice
Teucrium polium (Labiatae) is a plant that widely grows in Iran. Some of species of Teucrium are used for a considerable range of actions in traditional medicine and T. polium has frequently been used as anticonvulsant. In this study, we investigated the protective effects of T. polium ethanolic aqueous extracts and related fractions on seizures induced by pentylenetetrazole (PTZ) and maximal e...
متن کاملAnticonvulsant Activity of Teucrium polium Against Seizure Induced by PTZ and MES in Mice
Teucrium polium (Labiatae) is a plant that widely grows in Iran. Some of species of Teucrium are used for a considerable range of actions in traditional medicine and T. polium has frequently been used as anticonvulsant. In this study, we investigated the protective effects of T. polium ethanolic aqueous extracts and related fractions on seizures induced by pentylenetetrazole (PTZ) and maximal e...
متن کاملRetinol and ?-Carotene inhibit PTZ-induced kindling in mice
Vitamin A and its derivatives have recently reported to be implicated in synaptic plasticity. The possible effect of vitamin A and its precursor, ?-carotene, on seizure acquisition was tested in PTZ kindling model of epilepsy. Vitamin A and ?-carotene were tested for their ability to 1) suppress seizures (clonic and tonic) and lethality induced by PTZ in PTZ-kindled mice (anticonvulsant effect)...
متن کاملFructose-1,6-diphosphate inhibits seizure acquisition in fast hippocampal kindling.
Inhibition of glycolytic metabolism may provide a new therapy for refractory epilepsy. Fructose-1,6-diphosphate (FDP), which inhibits glycolysis and diverts glucose into the pentose phosphate pathway, has strong inhibitory action on seizures induced by chemical convulsants. Here, we investigated the effect of FDP on a rat model of rapid hippocampal kindling. After determining the after-discharg...
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ژورنال
عنوان ژورنال: Epilepsia
سال: 2011
ISSN: 0013-9580
DOI: 10.1111/j.1528-1167.2010.02889.x